Titre du document / Document title Isolation of doxycycline, 6-epidoxycycline and 2-acetyl-2-decarboxamidometacycline from commercial metacycline by preparative colum.Titre du document / Document title Rapid liquid chromatographic method for simultaneous determination of tetracyclines antibiotics and 6-epi-doxycycline in.A simple HPLC method for the separation of doxycycline and its degradation products 6-epidoxycycline and metacycline was developed.. high selectivity for tetracycline over the other structurally related tetracycline derivatives (oxytetracycline and doxycycline) in a mixture.